小的紅細(xì)胞可能預(yù)示著癌癥

小的紅細(xì)胞可能預(yù)示著癌癥

Having abnormally small red blood cells -- a condition known as microcytosis -- could indicate cancer, according to new research led by a University of Exeter student working with a world-leading team.

埃克塞特大學(xué)學(xué)生與世界領(lǐng)先的團(tuán)隊(duì)合作開展的一項(xiàng)新研究表明，患有異常小的紅細(xì)胞(一種稱為微細(xì)胞增多癥)可能表明癌癥。

Medical Sciences student Rhain Hopkins was lead author of the study of more than 12,000 UK patients aged over 40, which found that the cancer risk in males was 6.2 per cent, compared to 2.7 per cent in those without microcytosis.

醫(yī)學(xué)系學(xué)生Rhain Hopkins是這項(xiàng)研究的主要作者，該研究對12000多名40歲以上的英國患者進(jìn)行了調(diào)查，結(jié)果發(fā)現(xiàn)男性患癌癥的風(fēng)險(xiǎn)為6.2%，而那些沒有發(fā)生微細(xì)胞增生的患者的風(fēng)險(xiǎn)為2.7%。

The research, funded by Cancer Research UK and NIHR and published in BJGP, found that in females, the risk of cancer was 2.7 per cent in those with microcytosis, compared to 1.4 per cent without.

這項(xiàng)研究由英國癌癥研究所(Cancer research UK)和美國國立衛(wèi)生研究院(NIHR)資助，發(fā)表在BJGP上。研究發(fā)現(xiàn)，在女性中，有微細(xì)胞增多癥的人患癌癥的風(fēng)險(xiǎn)為2.7%，而沒有微細(xì)胞增多癥的人患癌癥的風(fēng)險(xiǎn)為1.4%。

Of more than 108,000 followed within the Clinical Practice Research Datalink records, 12,289 patients with microcytosis were followed up. Of those, 497 developed cancer within a year.

在臨床實(shí)踐研究數(shù)據(jù)鏈記錄的108000多例隨訪中，12289例微細(xì)胞增多癥患者得到隨訪。其中497人在一年內(nèi)患上癌癥。

Microcytosis is related to iron deficiency and with genetic conditions which affect haemaglobn in the blood. Similarly, iron deficiency has been identified as a feature of some cancers, particularly colorectal. Microcytosis is easily identified in a routine blood test.

微細(xì)胞增多與缺鐵有關(guān)，并與影響血液中血球的遺傳條件有關(guān)。同樣，缺鐵也被認(rèn)為是某些癌癥的一個(gè)特征，尤其是結(jié)直腸癌。在常規(guī)血液檢查中很容易發(fā)現(xiàn)微細(xì)胞增生。

Rhian Hopkins was working with Exeter's cancer diagnosis team as part of her Professional Training Year, which gives Medical Sciences students practical experience of research. As lead author of the paper, she said: "Research targeted at diagnosing cancer earlier is so important in reducing the burden of this devastating disease. The identification of risk markers, such as microcytosis, that are relevant to a range of cancers, can have a real impact in primary care. Being part of this research has been a very rewarding experience and getting my first paper published is such a massive achievement."

Rhian Hopkins在她的專業(yè)培訓(xùn)年中與?？巳氐陌┌Y診斷團(tuán)隊(duì)一起工作，為醫(yī)學(xué)專業(yè)的學(xué)生提供了實(shí)踐研究的經(jīng)驗(yàn)。作為該論文的主要作者，她說：“針對早期診斷癌癥的研究，對于減輕這種毀滅性疾病的負(fù)擔(dān)非常重要。與多種癌癥相關(guān)的危險(xiǎn)標(biāo)志物(如微細(xì)胞增多癥)的鑒定，可以參與這項(xiàng)研究是非常有益的經(jīng)歷，而發(fā)表第一篇論文是一項(xiàng)巨大的成就。”

Professor Willie Hamilton, at the University of Exeter Medical School, who oversaw the research, said: "Overall, the risk of cancer in patients with microcytosis was still low, however our research indicates a need to investigate cancer. In two patients with cancer out of three the possibility of cancer is fairly easy to identify. For the other third, symptoms are often vague, and don't clearly point to cancer. For these patients GPs have to use more subtle clues to recognise that cancer may be present. Small red cells have long been recognised with colon cancer, but this study shows that they are a much broader clue, alerting the doctor to the small possibility of one of several possible cancers."

負(fù)責(zé)這項(xiàng)研究的?？巳卮髮W(xué)醫(yī)學(xué)院的威利漢密爾頓教授說：“總的來說，微細(xì)胞增多癥患者患癌癥的風(fēng)險(xiǎn)仍然很低，但是我們的研究表明有必要對癌癥進(jìn)行研究。在三分之二的癌癥患者中，癌癥的可能性相當(dāng)容易識別。另外三分之一，癥狀通常是模糊的，并不明顯指向癌癥。對于這些病人，全球定位系統(tǒng)必須使用更微妙的線索來識別癌癥存在可能。小紅細(xì)胞早就被認(rèn)為與結(jié)腸癌有關(guān)，但這項(xiàng)研究表明，它們是一個(gè)更廣泛的線索，提醒醫(yī)生注意幾種可能的癌癥。”