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BBC News with Julie Candler.

The Egyptian security forces have carried out a day-long assault in Cairo on camps of supporters loyal to the ousted President Mohammed Morsi with the heavy loss of life. By evening the security forces backed by bulldozers have seized control of the main camp near the Rabaa al-Adawiya mosque. BBC’s Bethany Bell is in Cairo.

Early this morning, security forces moved in to disperse two protest camps with supporters of the Muslim Brotherhood President Mohammed Morsi have been holding out for weeks. There were violent clashes between riot police and the protestors. Shots were fired amid crowds of teargas. Protestors burned tyres and threw rocks. The authorities say they are now in controlof both camps. A curfew has been imposed in Cairo and in several provinces around the country.

The Health Ministry said that across Egypt 278 people have been killed including 43 policemen, many more are injured. But Muslim Brotherhood has said more than 2,000 people died in the clashes.

The United States has strongly condemned the violence against the protestors. The Secretary of State John Kerry said it was a serious blow to efforts of reconciliation. Kim Ghattas reports from Washington.

The American Secretary of State John Kerry said the violence in Egypt was deplorable and a real blow to reconciliation efforts. He called on all sides to take a step back. Mr. Kerry said theinterim government and the country’s generals had a unique responsibility to avoid anescalation. Mr. Kerry said that he has spoken to the Egyptian Foreign Minister Nabil el-Arabi and believed that a path to a political solution was still open but made more difficult by today’s violence.

Bradley Manning, the US soldier convicted of handling hundreds of thousands of secret documents to the Wikileaks organization has spoken for the first time during his trial. Private Manning told the sentence hearing he was sorry he had hurt people and the United States. The BBC’s David Willis is outside the court in Maryland.

Bradley Manning made a very brief prepared statement he addressed his remarks directly to the judge in the times. He even appeared to be on the verge of tears. He apologized repeatedly for what he done, he said I'm sorry that I hurt people, I'm sorry that I hurt the United States. Then added that he was dealing with a lot of issues at the time that he leaked that a slew of classified information. That wasn't an excuse, he said, but it was something to be borne in mind.

The Nigerian military says it's killed the second in command of Islamist group Boko Haram. It said Momodu Bama died during a Boko Haram attack in the northeastern state of Borno early this month. There has been no independent confirmation of his death. The armed forces have been carrying out operations against the groups since President Goodluck Jonathan declared an emergency in three northeastern states in May.

World News from the BBC.

Israeli and Palestinian representatives meeting in Jerusalem are reported to have begun their first direct negotiations in three years. The initial session is likely to focus on borders andsecurity. Our BBC correspondent says the talk has been held in a downbeat atmosphere. Earlier Israel released the first group of Palestinian prisoners freed as part of the negotiating process brokered by the Secretary of State John Kerry. But it also announced an expansionof its settlement program on occupied territory.

After 22 years the medical charity MSF said it's closing all its operations in Somalia. MSF’s international President Dr. Unni Karunakara said it had been one of the hardest decisions MSF ever made. Mark Doyle reports.

In many parts of the war-torn East African nation, the charity is the only provider of healthcare ranging from basic medical supplies to major surgery. MSF has always been famous for being the last charity to pull out of war zones. But the organization said a combination of its staff being killed, kidnapped or attacked had become intolerable. Fifteen hundred medical staff will stop work. The expatriates among them will leave and the Somalis will lose their jobs.

British scientists say they uncovered important new information about the way cancers develop. They have identified 21 types of genetic change on mutation that underline the most common types of the illness. Professor Alexandrov is a surgeon who was involved in study.

“We can actually start to see the very core changes we see in genes in the DNA of cancers and what that means is we can start to think about what actual processes are directly starting to damage the DNA. This is something we haven't really been able to do before.”

The results are based on the analysis.

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