Researchers in the US treated healthy mice with a form of gene therapy that refreshed older cells, making the animals more youthful according to biological markers that are used to measure the effects of aging.
美國(guó)研究人員對(duì)健康老鼠實(shí)施了一種更新老化細(xì)胞的基因療法并獲得成功,通過生物標(biāo)記法他們測(cè)出這些老鼠變年輕了。
The findings will fuel interest in radical new therapies that aim to slow or reverse the aging process as a means of tackling age-related diseases such as cancer, brittle bones and Alzheimer’s.
這一發(fā)現(xiàn)會(huì)點(diǎn)燃人們對(duì)以延緩或逆轉(zhuǎn)衰老為目標(biāo)的激進(jìn)新療法的興趣,這種療法可以用來治療癌癥、骨質(zhì)疏松和老年癡呆癥等老年常見疾病。
The scientists drew on previous work by the Japanese Nobel laureate Prof Shinya Yamanaka, who showed that a mixture of four molecules – known as Yamanaka factors – can rewind adult cells into youthful stem cells that are capable of forming almost any tissue in the body.
美國(guó)科學(xué)家的這一療法借鑒了日本諾貝爾獎(jiǎng)得主山中伸彌教授先前的研究成果。山中伸彌向世人展示,被稱為“山中因子”的四種分子組合在一起可以讓成人細(xì)胞逆生長(zhǎng)為年輕的干細(xì)胞,而干細(xì)胞可以分化成人體的任何組織。
The US team found that mice who received Yamanaka factors for several months resembled younger animals in many ways, with their skin and kidneys in particular showing signs of rejuvenation.
美國(guó)團(tuán)隊(duì)發(fā)現(xiàn),連續(xù)數(shù)月注射山中因子的老鼠在很多方面都變得像年輕老鼠,皮膚和腎臟的回春跡象尤為明顯。